Alchemia Story is an awesome RPG and adventure game developed by Asobimo Inc. Night before the Industrial Revolution, people gather to the city. To avoid Mamonos as youths grow up, you have to go on a journey to defeat Mao around the world and find where they belong.
There is a YOME system, another character to journey and help out each other with the player. Leading the way to the target, supporting the battle, and synthesizing the items etc. If you get stuck in the game, check out the video walkthrough and gameplay for the game.